http://www.peripheries.org/2009/04/03/disco-dosing-when-your-disco-kills-you-the-western-way/ Thu, 24 Mar 2011 07:39:18 +0000 hourly 1 http://wordpress.org/?v=3.1.2 http://www.peripheries.org/2009/04/03/disco-dosing-when-your-disco-kills-you-the-western-way/comment-page-1/#comment-315 Elizabeth Pisani Sun, 12 Apr 2009 12:46:52 +0000 http://www.peripheries.org/?p=1034#comment-315 While there's no evidence yet that PrEP works in humans, it's working very well in animal models. But here's the bad news. A study reported at CROI a couple of months ago compared the effect of taking PrEP consistently with taking it 12 hours before exposure and taking it just a couple of hours before exposure. The first two worked, the "disco dosing" didn't. Or rather, it didn't if you weren't planning to be in the disco for 12 hours before you went to the back room. By which time the effect of the M would have long worn off. (In my own get-rich-quick formulation I was planning to substitute E for meth, but that wouldn't work any better...) While there's no evidence yet that PrEP works in humans, it's working very well in animal models. But here's the bad news. A study reported at CROI a couple of months ago compared the effect of taking PrEP consistently with taking it 12 hours before exposure and taking it just a couple of hours before exposure. The first two worked, the "disco dosing" didn't. Or rather, it didn't if you weren't planning to be in the disco for 12 hours before you went to the back room. By which time the effect of the M would have long worn off. (In my own get-rich-quick formulation I was planning to substitute E for meth, but that wouldn't work any better…)

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